A peptide inducer of experimental autoimmune uveoretinitis
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IRBP (651-670) (human) (trifluoroacetate salt)

Item No. 36953

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-alanyl-L-glutaminylglycyl-L-alanyl-L-tyrosyl-L-arginyl-L-threonyl-L-alanyl-L-valyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-seryl-L-leucyl-L-alanyl-L-seryl-L-glutaminyl-L-leucyl-L-threonine, trifluoroacetate salt
Synonyms
  • Interphotoreceptor Retinoid-Binding Protein (651-670)
  • IRBP651-670
Molecular Formula
C91H151N25O32 • XCF3COOH
Formula Weight
2107.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
LAQGAYRTAVDLESLASQLT-OH
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/ml
SMILES
CC(C)C[C@@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@]([C@H](O)C)([H])C(O)=O)=O)CC(C)C)=O)=O)=O)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)C)=O)N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C91H151N25O32.C2HF3O2/c1-39(2)30-52(92)76(133)100-45(12)73(130)103-54(23-26-64(93)122)77(134)98-36-66(124)99-44(11)72(129)107-60(34-50-19-21-51(121)22-20-50)83(140)104-53(18-17-29-97-91(95)96)80(137)115-70(48(15)119)89(146)102-47(14)75(132)114-69(43(9)10)88(145)111-61(35-68(127)128)84(141)109-58(32-41(5)6)82(139)105-56(25-28-67(125)126)79(136)113-63(38-118)87(144)110-57(31-40(3)4)81(138)101-46(13)74(131)112-62(37-117)86(143)106-55(24-27-65(94)123)78(135)108-59(33-42(7)8)85(142)116-71(49(16)120)90(147)148;3-2(4,5)1(6)7/h19-22,39-49,52-63,69-71,117-121H,17-18,23-38,92H2,1-16H3,(H2,93,122)(H2,94,123)(H,98,134)(H,99,124)(H,100,133)(H,101,138)(H,102,146)(H,103,130)(H,104,140)(H,105,139)(H,106,143)(H,107,129)(H,108,135)(H,109,141)(H,110,144)(H,111,145)(H,112,131)(H,113,136)(H,114,132)(H,115,137)(H,116,142)(H,125,126)(H,127,128)(H,147,148)(H4,95,96,97);(H,6,7)/t44-,45-,46-,47-,48+,49+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,69-,70-,71-;/m0./s1
InChi Key
SXKFLEPZATZNNY-NDTDTKSPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $31

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    5 mg

    $147

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    10 mg

    $278

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    25 mg

    $539

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    Product Description

    Interphotoreceptor retinoid-binding protein (651-670) (IRBP651-670) is a peptide fragment of IRBP, also known as retinoid-binding protein 3, which is involved in pigment regeneration by transporting retinol and retinal from photoreceptor cells to retinal pigment epithelium.1,2 IRBP651-670 has been used to induce autoimmune uveoretinitis in C57BL/6 mice, which bear the H-2b haplotype. Immunization with IRBP651-670 (300 µg/animal) increases ocular IL-1β, IL-6, IL-17, TNF-α, and IFN-γ levels, immune cell infiltration, and photoreceptor damage in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mattapallil, M.J., Silver, P.B., Cortes, L.M., et al. Characterization of a new epitope of IRBP that induces moderate to severe uveoretinitis in mice with H-2b haplotype. Invest. Ophthalmol. Vis. Sci. 56(9), 5439-5449 (2015).

    2. Zeng, S., T., Z., Madigan, M.C., et al. Interphotoreceptor retinoid-binding protein (IRBP) in retinal health and disease. Front. Cell. Neurosci. 14, 577935 (2020).