An antimicrobial peptide
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AMPR-22 (trifluoroacetate salt)

Item No. 36954

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-lysyl-L-methionyl-L-methionyl-L-lysyl-L-lysylglycylglycyl-L-lysyl-L-phenylalanylglycyl-L-threonyl-L-phenylalanyl-L-methionyl-L-arginine, trifluoroacetate salt
Synonyms
  • KKMMKKGGKFGTFMAIGGIR
Molecular Formula
C98H168N28O22S3 • XCF3COOH
Formula Weight
2186.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 11 mg/mL
SMILES
OC(C(F)(F)F)=O.O=C(N[C@@H](CCCCN[H])C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(NCC(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@](C(NCC(NCC(N[C@@](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H]
InChi Code
InChI=1S/C98H168N28O22S3.C2HF3O2/c1-10-58(3)80(94(144)112-54-76(129)109-56-78(131)124-81(59(4)11-2)95(145)121-72(97(147)148)38-28-47-107-98(105)106)126-83(133)60(5)113-87(137)69(39-48-149-7)120-93(143)74(52-63-31-16-13-17-32-63)123-96(146)82(61(6)127)125-79(132)57-111-86(136)73(51-62-29-14-12-15-30-62)122-88(138)66(35-20-25-44-101)114-77(130)55-108-75(128)53-110-85(135)65(34-19-24-43-100)116-90(140)68(37-22-27-46-103)117-91(141)70(40-49-150-8)119-92(142)71(41-50-151-9)118-89(139)67(36-21-26-45-102)115-84(134)64(104)33-18-23-42-99;3-2(4,5)1(6)7/h12-17,29-32,58-61,64-74,80-82,127H,10-11,18-28,33-57,99-104H2,1-9H3,(H,108,128)(H,109,129)(H,110,135)(H,111,136)(H,112,144)(H,113,137)(H,114,130)(H,115,134)(H,116,140)(H,117,141)(H,118,139)(H,119,142)(H,120,143)(H,121,145)(H,122,138)(H,123,146)(H,124,131)(H,125,132)(H,126,133)(H,147,148)(H4,105,106,107);(H,6,7)/t58-,59-,60-,61+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,80-,81-,82-;/m0./s1
InChi Key
ODSLLZBJJIALDP-JWTDGOCASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    AMPR-22 is a synthetic antimicrobial peptide derived from the mitochondrial cation channel reactive oxygen species (ROS) modulator 1 (Romo1).1 It is active against S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and carbapenem-resistant P. aeruginosa with minimum bactericidal concentration (MBC) values of 2, 2, 2, and 4 µg/ml, respectively. AMPR-22 induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa in a concentration-dependent manner. It increases survival in a mouse model of sepsis induced by S. aureus when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. You, D.-G., Lee, H.-R., Kim, H.-K., et al. A novel peptide derived from the transmembrane domain of Romo1 is a promising candidate for sepsis treatment and multidrug-resistant bacteria. Int. J. Mol. Sci. 22(15), 8243 (2021).