A peptide inhibitor of the CXCL8-GAG interaction
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E70K (trifluoroacetate salt)

Item No. 36956

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C108H178N34O28 • XCF3COOH
Formula Weight
2400.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-KENWVQRVVEKFLKRAKNS-NH2
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
OC(C(F)(F)F)=O.OC(CC[C@H](NC([C@H](CCCCN)NC(C)=O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C108H178N34O28.C2HF3O2/c1-55(2)48-74(99(163)130-67(32-18-22-44-111)92(156)128-69(34-24-46-121-107(117)118)90(154)124-59(9)89(153)126-66(31-17-21-43-110)93(157)137-78(52-82(115)147)102(166)139-79(54-143)88(116)152)134-100(164)75(49-61-26-12-11-13-27-61)135-94(158)68(33-19-23-45-112)127-96(160)73(38-41-84(150)151)133-105(169)86(57(5)6)142-106(170)87(58(7)8)140-98(162)70(35-25-47-122-108(119)120)129-95(159)71(36-39-80(113)145)132-104(168)85(56(3)4)141-103(167)76(50-62-53-123-64-29-15-14-28-63(62)64)136-101(165)77(51-81(114)146)138-97(161)72(37-40-83(148)149)131-91(155)65(125-60(10)144)30-16-20-42-109;3-2(4,5)1(6)7/h11-15,26-29,53,55-59,65-79,85-87,123,143H,16-25,30-52,54,109-112H2,1-10H3,(H2,113,145)(H2,114,146)(H2,115,147)(H2,116,152)(H,124,154)(H,125,144)(H,126,153)(H,127,160)(H,128,156)(H,129,159)(H,130,163)(H,131,155)(H,132,168)(H,133,169)(H,134,164)(H,135,158)(H,136,165)(H,137,157)(H,138,161)(H,139,166)(H,140,162)(H,141,167)(H,142,170)(H,148,149)(H,150,151)(H4,117,118,121)(H4,119,120,122);(H,6,7)/t59-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,85-,86-,87-;/m0./s1
InChi Key
FUGRRZPKIYKQRT-LSZCLUPISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    E70K is an inhibitor of the chemokine-glycosaminoglycan interaction between chemokine (C-X-C) ligand 8 (CXCL8) and glycosaminoglycans (GAGs) on the exterior of cell membranes.1 It corresponds to an amino acid sequence from the CXCL8 C-terminal GAG-binding region and contains a glutamate-to-lysine substitution at position 70. E70K (50 nM) inhibits primary human neutrophil binding to human umbilical vein endothelial cells (HUVECs). It decreases CXCL8-induced transendothelial migration of primary human neutrophils through HMEC-1 human microvascular endothelial cell layers when used at concentrations ranging from 1 to 1,000 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martínez-Burgo, B., Cobb, S.L., Pohl, E., et al. A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation. Immunology 157(2), 173-184 (2019).