An αVβ6 integrin-binding peptide
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
ECM & Adhesion Molecules

A20FMDV2 (trifluoroacetate salt)

Item No. 36958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginyl-L-alanyl-L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-arginylglycyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-L-valyl-L-alanyl-L-arginyl-L-threonine, trifluoroacetate salt
Molecular Formula
C93H163N31O28 • XCF3COOH
Formula Weight
2163.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
NAVPNLRGDLQVLAQKVART-OH
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC(C(F)(F)F)=O.O=C(N[C@H](C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)C)[C@H](CC(N)=O)N[H]
InChi Code
InChI=1S/C93H163N31O28.C2HF3O2/c1-41(2)34-57(82(142)108-47(13)73(133)112-55(26-28-63(96)126)78(138)114-53(22-17-18-30-94)79(139)120-69(44(7)8)88(148)109-48(14)74(134)111-54(24-20-32-105-93(102)103)80(140)123-72(50(16)125)91(151)152)119-89(149)70(45(9)10)121-81(141)56(27-29-64(97)127)115-84(144)59(36-43(5)6)117-86(146)61(39-68(131)132)110-67(130)40-106-77(137)52(23-19-31-104-92(100)101)113-83(143)58(35-42(3)4)116-85(145)60(38-66(99)129)118-87(147)62-25-21-33-124(62)90(150)71(46(11)12)122-75(135)49(15)107-76(136)51(95)37-65(98)128;3-2(4,5)1(6)7/h41-62,69-72,125H,17-40,94-95H2,1-16H3,(H2,96,126)(H2,97,127)(H2,98,128)(H2,99,129)(H,106,137)(H,107,136)(H,108,142)(H,109,148)(H,110,130)(H,111,134)(H,112,133)(H,113,143)(H,114,138)(H,115,144)(H,116,145)(H,117,146)(H,118,147)(H,119,149)(H,120,139)(H,121,141)(H,122,135)(H,123,140)(H,131,132)(H,151,152)(H4,100,101,104)(H4,102,103,105);(H,6,7)/t47-,48-,49-,50+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,69-,70-,71-,72-;/m0./s1
InChi Key
WBVXQGMOOYFVAG-SIHAKCMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

    $262

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    10 mg

    $469

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    25 mg

    $1,032

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    Product Description

    A20FMDV2 is a peptide that comprises the α-helical RGD cell-interacting domain on the VP1 capsid protein from foot-and-mouth disease virus (FMDV) serotype O and binds to αVβ6 integrin.1 It inhibits αVβ6 integrin-dependent cell adhesion in H357 tongue squamous cell carcinoma cells expressing human αVβ6 (IC50 = 1.2 µM). When coupled with 111indium-DTPA, A20FMDV2 (20 MBq) binds to αVβ6 integrin endogenously expressed for radiation imaging analysis in a MCF10CA1a breast cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DiCara, D., Rapisarda, C., Sutcliffe, J.L., et al. Structure-function analysis of Arg-Gly-Asp helix motifs in αvβ6 integrin ligands. The Journal of Biological Chemisty 282(13), 9657-9665 (2007).

    2. Saha, A., Ellison, D., Thomas, G.J., et al. High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin αvβ6. J. Pathol. 222(1), 52-63 (2010).