An antimicrobial peptide
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BMAP 28 (bovine) (trifluoroacetate salt)

Item No. 36960

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycylglycyl-L-leucyl-L-arginyl-L-seryl-L-leucylglycyl-L-arginyl-L-lysyl-L-isoleucyl-L-leucyl-L-arginyl-L-alanyl-L-tryptophyl-L-lysyl-L-lysyl-L-tyrosylglycyl-L-prolyl-L-isoleucyl-L-isoleucyl-L-valyl-L-prolyl-L-isoleucyl-L-isoleucyl-L-arginyl-L-isoleucinamide, trifluoroacetate salt
Synonyms
  • Bovine Myeloid Antimicrobial Peptide 28
  • Cathelicidin-5 (132-158)
Molecular Formula
C145H250N44O29 • XCF3COOH
Formula Weight
3073.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GGLRSLGRKILRAWKKYGPIIVPIIRI-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.[H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H](NC(CNC(CN[H])=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC(C=C3)=CC=C3O)C(NCC(N4CCC[C@H]4C(N[C@@](C(N[C@@](C(N[C@@H](C(C)C)C(N5CCC[C@H]5C(N[C@@](C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N)=O)([H])[C@H](CC)C)=O)=O)([H])[C@H](CC)C)=O)([H])[C@H](CC)C)=O)=O)=O)([H])[C@H](CC)C)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC(C)C)=O)([H])[C@H](CC)C)=O
InChi Code
InChI=1S/C145H250N44O29.C2HF3O2/c1-22-81(15)113(119(150)196)182-128(205)99(50-39-63-162-145(157)158)175-136(213)115(83(17)24-3)186-139(216)117(85(19)26-5)185-135(212)107-52-41-65-189(107)141(218)112(80(13)14)181-138(215)118(86(20)27-6)187-140(217)116(84(18)25-4)184-134(211)106-51-40-64-188(106)111(195)75-166-122(199)103(69-88-53-55-90(191)56-54-88)178-126(203)95(45-31-34-58-147)170-125(202)94(44-30-33-57-146)172-132(209)104(70-89-72-163-92-43-29-28-42-91(89)92)176-120(197)87(21)167-123(200)97(48-37-61-160-143(153)154)173-131(208)102(68-79(11)12)179-137(214)114(82(16)23-2)183-129(206)96(46-32-35-59-148)171-124(201)93(47-36-60-159-142(151)152)168-110(194)74-165-121(198)100(66-77(7)8)177-133(210)105(76-190)180-127(204)98(49-38-62-161-144(155)156)174-130(207)101(67-78(9)10)169-109(193)73-164-108(192)71-149;3-2(4,5)1(6)7/h28-29,42-43,53-56,72,77-87,93-107,112-118,163,190-191H,22-27,30-41,44-52,57-71,73-76,146-149H2,1-21H3,(H2,150,196)(H,164,192)(H,165,198)(H,166,199)(H,167,200)(H,168,194)(H,169,193)(H,170,202)(H,171,201)(H,172,209)(H,173,208)(H,174,207)(H,175,213)(H,176,197)(H,177,210)(H,178,203)(H,179,214)(H,180,204)(H,181,215)(H,182,205)(H,183,206)(H,184,211)(H,185,212)(H,186,216)(H,187,217)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161)(H4,157,158,162);(H,6,7)/t81-,82-,83-,84-,85-,86-,87-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,112-,113-,114-,115-,116-,117-,118-;/m0./s1
InChi Key
VUDOLZSJPFRNHA-BVZWWGGDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Bovine myeloid antimicrobial peptide (BMAP) 28 is a synthetic antimicrobial peptide that corresponds to amino acids 132-158 of bovine cathelicidin-5.1 It is active against the bacteria E. coli, S. aureus, methicillin-resistant S. aureus (MRSA), and S. epidermidis and the fungus C. albicans (MICs = 2, 2, 4, 1, and 8 µM, respectively). BMAP 28 induces inner membrane permeabilization in E. coli when used at a concentration of 200 nM. It reduces viral replication of herpes simplex virus 1 (HSV-1) in Vero 76-infected cells when used at a concentration of 5 µM.2 It induces hemolysis of isolated human erythrocytes and is cytotoxic to isolated human neutrophils when used at a concentration of 30 µM.1 BMAP 28 (0.8 mg/kg) increases survival in E. coli- or MRSA-infected mice but not P. aeruginosa-infected mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Skerlavaj, B., Gennaro, R., Bagella, L., et al. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. The Journal of Biological Chemisty 271(45), 28375-28381 (1996).

    2. Benincasa, M., Skerlavaj, B., Gennaro, R., et al. In vitro and in vivo antimicrobial activity of two α-helical cathelicidin peptides and of their synthetic analogs. Peptides 24(11), 1723-1731 (2003).