A peptide inhibitor of the CXCL12-HMGB1 protein-protein interaction
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation
Adaptive Immunity

HBP08 (trifluoroacetate salt)

Item No. 36961

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tyrosyl-L-histidyl-L-tyrosyl-L-α-glutamyl-L-arginyl-L-tryptophyl-L-isoleucyl-L-histidine, trifluoroacetate salt
Molecular Formula
C60H77N17O14 • XCF3COOH
Formula Weight
1260.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GYHYERWIH-OH
Solubility(Learn about Variance in Solubility)
Water: Sparingly soluble: 1-10 mg/ml
SMILES
OC(C(F)(F)F)=O.OC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC2=CC=C(C=C2)O)=O)CC3=CN=CN3)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O
InChi Code
InChI=1S/C60H77N17O14.C2HF3O2/c1-3-32(2)51(58(89)76-48(59(90)91)25-37-29-65-31-69-37)77-57(88)46(23-35-27-67-41-8-5-4-7-40(35)41)74-52(83)42(9-6-20-66-60(62)63)71-53(84)43(18-19-50(81)82)72-55(86)45(22-34-12-16-39(79)17-13-34)73-56(87)47(24-36-28-64-30-68-36)75-54(85)44(70-49(80)26-61)21-33-10-14-38(78)15-11-33;3-2(4,5)1(6)7/h4-5,7-8,10-17,27-32,42-48,51,67,78-79H,3,6,9,18-26,61H2,1-2H3,(H,64,68)(H,65,69)(H,70,80)(H,71,84)(H,72,86)(H,73,87)(H,74,83)(H,75,85)(H,76,89)(H,77,88)(H,81,82)(H,90,91)(H4,62,63,66);(H,6,7)/t32-,42-,43-,44-,45-,46-,47-,48-,51-;/m0./s1
InChi Key
FOGBNJKPHOMXCH-PMPJGRMFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $195

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    10 mg

    $358

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    25 mg

    $812

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    Product Description

    HBP08 is a peptide inhibitor of the protein-protein interaction between chemokine (C-X-C motif) ligand 12 (CXCL12) and high mobility group protein B1 (HMGB1).1 It binds to HMGB1 (Kd = 0.8 µM) and inhibits HMGB1-induced inhibition of CXCL12-induced migration of 300-19 pre-B cells expressing human chemokine (C-X-C motif) receptor 4 (CXCR4).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sgrignani, J., Cecchinato, V., Fassi, E.M.A., et al. Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction. J. Med. Chem. 64(18), 13439-13450 (2021).