A Bim-derived peptide
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BimS BH3 (51-76) (human) (trifluoroacetate salt)

Item No. 36963

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-methionyl-L-arginyl-L-prolyl-L-α-glutamyl-L-isoleucyl-L-tryptophyl-L-isoleucyl-L-alanyl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucylglycyl-L-α-aspartyl-L-α-glutamyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-arginyl-L-arginine, trifluoroacetate salt
Synonyms
  • DMRPEIWIAQELRRIGDEFNAYYARR-OH
  • Bims (51-76)
Molecular Formula
C145H222N44O41S • XCF3COOH
Formula Weight
3269.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
SMILES
OC(C(F)(F)F)=O.O=C(O)C[C@H](N[H])C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)CC(C)C)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C145H222N44O41S.C2HF3O2/c1-13-72(6)113(136(225)165-70-107(194)169-103(68-112(203)204)133(222)176-92(47-51-109(197)198)124(213)182-100(62-78-27-17-16-18-28-78)132(221)184-102(67-106(148)193)129(218)167-76(10)118(207)180-99(64-80-39-43-83(191)44-40-80)131(220)183-98(63-79-37-41-82(190)42-38-79)128(217)166-75(9)116(205)170-87(31-21-54-159-141(149)150)121(210)179-96(140(229)230)35-25-58-163-145(157)158)186-126(215)89(33-23-56-161-143(153)154)173-120(209)88(32-22-55-160-142(151)152)174-130(219)97(61-71(4)5)181-123(212)91(46-50-108(195)196)175-122(211)90(45-49-105(147)192)171-117(206)77(11)168-137(226)114(73(7)14-2)188-134(223)101(65-81-69-164-86-30-20-19-29-84(81)86)185-138(227)115(74(8)15-3)187-127(216)93(48-52-110(199)200)177-135(224)104-36-26-59-189(104)139(228)95(34-24-57-162-144(155)156)178-125(214)94(53-60-231-12)172-119(208)85(146)66-111(201)202;3-2(4,5)1(6)7/h16-20,27-30,37-44,69,71-77,85,87-104,113-115,164,190-191H,13-15,21-26,31-36,45-68,70,146H2,1-12H3,(H2,147,192)(H2,148,193)(H,165,225)(H,166,217)(H,167,218)(H,168,226)(H,169,194)(H,170,205)(H,171,206)(H,172,208)(H,173,209)(H,174,219)(H,175,211)(H,176,222)(H,177,224)(H,178,214)(H,179,210)(H,180,207)(H,181,212)(H,182,213)(H,183,220)(H,184,221)(H,185,227)(H,186,215)(H,187,216)(H,188,223)(H,195,196)(H,197,198)(H,199,200)(H,201,202)(H,203,204)(H,229,230)(H4,149,150,159)(H4,151,152,160)(H4,153,154,161)(H4,155,156,162)(H4,157,158,163);(H,6,7)/t72-,73-,74-,75-,76-,77-,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-;/m0./s1
InChi Key
SFHGBFCIOJQZFB-NNBNUYNFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    BimS BH3 (51-76) is a peptide that corresponds to amino acids 51-76 of the short splice variant of the pro-apoptotic protein Bim (BimS), which contains the Bcl-2 homology 3 (BH3) motif.1 It binds to myeloid cell leukemia-1 (Mcl-1), Bcl-xL, Bcl-2, and Bcl-W (IC50s = 18, 10, 7, and 18 nM, respectively). BimS BH3 (51-76) induces cytochrome c release from mitochondria derived from bcl-x-/- mouse embryonic fibroblasts (MEFs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, E.F., Fedorova, A., Zobel, K., et al. Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. The Journal of Biological Chemisty 284(45), 31315-31326 (2009).