A fluorogenic substrate for MMPs
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Mca-KPLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)

Item No. 36965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide, monotrifluoroacetate salt
CAS Number
1392300-20-7
Synonyms
  • Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl)
  • FS-6
Molecular Formula
C55H80N16O16 • CF3COOH
Formula Weight
1335.4
Purity
≥95%
Emission
420 nm
Excitation
328 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
λmax
329 nm
SMILES
OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O
InChi Code
InChI=1S/C55H80N16O16.C2HF3O2/c1-29(2)21-39(67-53(80)42-13-10-20-69(42)54(81)38(11-7-8-18-56)64-45(72)23-32-24-47(74)87-44-26-34(86-6)15-16-35(32)44)50(77)62-28-46(73)65-40(22-30(3)4)51(78)68-41(27-61-36-17-14-33(70(82)83)25-43(36)71(84)85)52(79)63-31(5)49(76)66-37(48(57)75)12-9-19-60-55(58)59;3-2(4,5)1(6)7/h14-17,24-26,29-31,37-42,61H,7-13,18-23,27-28,56H2,1-6H3,(H2,57,75)(H,62,77)(H,63,79)(H,64,72)(H,65,73)(H,66,76)(H,67,80)(H,68,78)(H4,58,59,60);(H,6,7)/t31-,37-,38-,39-,40-,41-,42-;/m0./s1
InChi Key
DLAVUILBJVTDAO-NMZYGPKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Mca-KPLGL-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinases (MMPs).1 Upon cleavage by MMPs, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neumann, U., Kubota, H., Frei, K., et al. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Anal. Biochem. 328(2), 166-173 (2004).