A peptide agonist of CXCR7
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LIH383 (trifluoroacetate salt)

Item No. 36967

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-6-amino-2-((2S,5S,8S,11S,20S)-20-amino-11-benzyl-2,5-bis(3-guanidinopropyl)-8-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-21-phenyl-3,6,9,12,15,18-hexaazahenicosanamido)hexanamide, trifluoroacetate salt
Synonyms
  • Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2
Molecular Formula
C45H72N16O8S • XCF3COOH
Formula Weight
997.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
FGGFMRRK-NH2
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C(F)(F)F)=O.O=C([C@H](CC1=CC=CC=C1)N)NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCSC)=O)=O)=O
InChi Code
InChI=1S/C45H72N16O8S.C2HF3O2/c1-70-23-19-34(61-43(69)35(25-29-14-6-3-7-15-29)57-37(63)27-55-36(62)26-56-39(65)30(47)24-28-12-4-2-5-13-28)42(68)60-33(18-11-22-54-45(51)52)41(67)59-32(17-10-21-53-44(49)50)40(66)58-31(38(48)64)16-8-9-20-46;3-2(4,5)1(6)7/h2-7,12-15,30-35H,8-11,16-27,46-47H2,1H3,(H2,48,64)(H,55,62)(H,56,65)(H,57,63)(H,58,66)(H,59,67)(H,60,68)(H,61,69)(H4,49,50,53)(H4,51,52,54);(H,6,7)/t30-,31-,32-,33-,34-,35-;/m0./s1
InChi Key
NDERINDLRSIQOH-SKTOPIDTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $60

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    5 mg

    $263

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    10 mg

    $468

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    25 mg

    $1,022

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    Product Description

    LIH383 is a peptide agonist of chemokine (C-X-C motif) receptor 7 (CXCR7), a chemokine and opioid peptide scavenger receptor.1 It selectively activates CXCR7 (EC50 = 0.61 nM) over μ-, δ-, and κ-opioid receptors and the nociceptin opioid peptide (NOP) receptor in β-arrestin recruitment assays at 3 µM. LIH383 (3 µM) prevents CXCR7 uptake of opioid peptides induced by the non-selective opioid receptor agonist dynorphin A (Item No. 18169) in U87-ACKR3 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meyrath, M., Szpakowska, M., Zeiner, J., et al. The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat. Commun. 11(1), 3033 (2020).