A peptide substrate for Abl
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Abl Substrate Peptide (trifluoroacetate salt)

Item No. 36969

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt
Molecular Formula
C64H101N15O16 • XCF3COOH
Formula Weight
1336.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
EAIYAAPFAKKK-OH
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@H]2N(CCC2)C([C@H](C)NC([C@H](C)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C64H101N15O16.C2HF3O2/c1-7-36(2)52(78-55(85)39(5)69-56(86)44(68)28-29-51(81)82)62(92)77-49(35-42-24-26-43(80)27-25-42)60(90)70-37(3)53(83)72-40(6)63(93)79-33-17-23-50(79)61(91)76-48(34-41-18-9-8-10-19-41)59(89)71-38(4)54(84)73-45(20-11-14-30-65)57(87)74-46(21-12-15-31-66)58(88)75-47(64(94)95)22-13-16-32-67;3-2(4,5)1(6)7/h8-10,18-19,24-27,36-40,44-50,52,80H,7,11-17,20-23,28-35,65-68H2,1-6H3,(H,69,86)(H,70,90)(H,71,89)(H,72,83)(H,73,84)(H,74,87)(H,75,88)(H,76,91)(H,77,92)(H,78,85)(H,81,82)(H,94,95);(H,6,7)/t36-,37-,38-,39-,40-,44-,45-,46-,47-,48-,49-,50-,52-;/m0./s1
InChi Key
GYLBWCHBRIWMHZ-IGTABNFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    5 mg

    $296

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    10 mg

    $505

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    25 mg

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    Product Description

    Abl substrate peptide is a peptide substrate for the tyrosine kinase Abl.1 It is selectively phosphorylated by Abl over c-Src kinase at 20 µM. Abl substrate peptide has been used to quantify Abl kinase activity in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Songyang, Z., Carraway, K.L., 3rd., Eck, M.J., et al. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373(6514), 536-539 (1995).

    2. Kharbanda, S., Ren, R., Pandey, P., et al. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 376(6543), 785-788 (1995).