A peptide syntenin inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cancer
Cell Death

KSL-128114 (trifluoroacetate salt)

Item No. 36984

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((R)-2-((S)-2-((R)-2-((S)-2-((R)-2-(2-((R)-2-((S)-2-((R)-2-acetamido-5-guanidinopentanamido)-5-guanidinopentanamido)-5-guanidinopentanamido)acetamido)-5-guanidinopentanamido)-6-aminohexanamido)-6-aminohexanamido)-5-guanidinopentanamido)-5-guanidinopentanamido)-3-hydroxypropanamido)-3-(1H-imidazol-5-yl)propanamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-2-cyclohexylacetyl)-L-aspartyl-L-isoleucine, trifluoroacetate salt
Synonyms
  • Ac-rRrGrKkRrSHWX1X2DI-OH (X1=tert-Leucine; X2=Cyclohexylglycine)
Molecular Formula
C96H165N39O21 • XCF3COOH
Formula Weight
2201.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C(F)(F)F)=O.N=C(N)NCCC[C@@H](NC(C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(NCC(N[C@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@@H](C(C)(C)C)C(N[C@@H](C2CCCCC2)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C96H165N39O21.C2HF3O2/c1-7-51(2)72(89(155)156)133-84(150)68(45-71(139)140)131-87(153)73(53-23-9-8-10-24-53)134-88(154)74(96(4,5)6)135-85(151)66(43-54-46-118-57-26-12-11-25-56(54)57)129-83(149)67(44-55-47-111-50-120-55)130-86(152)69(49-136)132-82(148)65(34-22-42-117-95(109)110)128-81(147)64(33-21-41-116-94(107)108)127-79(145)62(28-14-16-36-98)125-78(144)61(27-13-15-35-97)124-77(143)60(31-19-39-114-92(103)104)122-70(138)48-119-75(141)58(29-17-37-112-90(99)100)123-80(146)63(32-20-40-115-93(105)106)126-76(142)59(121-52(3)137)30-18-38-113-91(101)102;3-2(4,5)1(6)7/h11-12,25-26,46-47,50-51,53,58-69,72-74,118,136H,7-10,13-24,27-45,48-49,97-98H2,1-6H3,(H,111,120)(H,119,141)(H,121,137)(H,122,138)(H,123,146)(H,124,143)(H,125,144)(H,126,142)(H,127,145)(H,128,147)(H,129,149)(H,130,152)(H,131,153)(H,132,148)(H,133,150)(H,134,154)(H,135,151)(H,139,140)(H,155,156)(H4,99,100,112)(H4,101,102,113)(H4,103,104,114)(H4,105,106,115)(H4,107,108,116)(H4,109,110,117);(H,6,7)/t51-,58+,59+,60+,61-,62+,63-,64-,65+,66-,67-,68-,69-,72-,73-,74+;/m0./s1
InChi Key
RMHFOFDMWDLKCE-CEIWRPBYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $128

    Add

    10 mg

    $225

    Add

    25 mg

    $492

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    KSL-128114 is a peptide inhibitor of the membrane regulator syntenin (Ki = 300 nM).1 It reduces the percent viability of A2058 melanoma and patient-derived glioblastoma multiforme (GBM) cells in a concentration-dependent manner. KSL-128114 (50 µM) increases animal survival time in a patient-derived xenograft (PDX) mouse model of GBM using patient-derived GBM cells cultured with KSL-128114 prior to intracranial implantation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haugaard-Kedström, L.M., Clemmensen, L.S., Sereikaite, V., et al. A high-affinity peptide ligand targeting syntenin inhibits glioblastoma. J. Med. Chem. 64(3), 1423-1434 (2021).