A fluorogenic substrate for SARS-CoV Mpro
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Mca-AVLQSGFR-K(Dnp)-K-NH2 (trifluoroacetate salt)

Item No. 37002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-lysinamide, trifluoroacetate salt
Molecular Formula
C69H99N19O20 • XCF3COOH
Formula Weight
1514.7
Purity
≥98%
Emission
420 nm
Excitation
328 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
20% ACN/H2O: soluble
SMILES
NCCCC[C@@H](C(N)=O)NC([C@H](CCCCNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=CC=C2)NC(CNC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](C)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C69H99N19O20.C2HF3O2/c1-37(2)29-50(84-68(102)59(38(3)4)86-61(95)39(5)78-56(91)31-41-32-58(93)108-54-34-43(107-6)21-22-44(41)54)66(100)83-49(24-25-55(71)90)65(99)85-52(36-89)62(96)77-35-57(92)79-51(30-40-15-8-7-9-16-40)67(101)82-48(19-14-28-76-69(73)74)64(98)81-47(63(97)80-46(60(72)94)17-10-12-26-70)18-11-13-27-75-45-23-20-42(87(103)104)33-53(45)88(105)106;3-2(4,5)1(6)7/h7-9,15-16,20-23,32-34,37-39,46-52,59,75,89H,10-14,17-19,24-31,35-36,70H2,1-6H3,(H2,71,90)(H2,72,94)(H,77,96)(H,78,91)(H,79,92)(H,80,97)(H,81,98)(H,82,101)(H,83,100)(H,84,102)(H,85,99)(H,86,95)(H4,73,74,76);(H,6,7)/t39-,46-,47-,48-,49-,50-,51-,52-,59-;/m0./s1
InChi Key
CGCVIXNKWNLLJP-OUHUHHCFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Mca-AVLQSGFR-K(Dnp)-K-NH2 is a fluorogenic substrate for severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), also known as 3C-like protease (3CLpro).1 Upon cleavage by SARS-CoV Mpro, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify SARS-CoV Mpro activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, X., Yang, H., Shen, W., et al. Production of authentic SARS-CoV Mpro with enhanced activity: Application as a novel tag-cleavage endopeptidase for protein overproduction. J. Mol. Biol. 366(3), 965-975 (2007).