A synthetic peptide fragment of caveolin-1
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Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 37003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartylglycyl-L-isoleucyl-L-tryptophyl-L-lysyl-L-alanyl-L-seryl-L-phenylalanyl-L-threonyl-L-threonyl-L-phenylalanyl-L-threonyl-L-valyl-L-threonyl-L-lysyl-L-tyrosyl-L-tryptophyl-L-phenylalanyl-L-tyrosyl-L-arginine, trifluoroacetate salt
Synonyms
  • Cav-1
  • Caveolin-1 Scaffolding Domain Peptide
  • CSD
  • CSP
  • DGIWKASFTTFTVTKYWFYR-NH2
Molecular Formula
C124H170N28O29 • XCF3COOH
Formula Weight
2516.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 3 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@H](C(NCC(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)=O)CC8=CNC9=C8C=CC=C9)=O)=O)=O)CC(O)=O
InChi Code
InChI=1S/C124H170N28O29.C2HF3O2/c1-10-66(4)100(147-97(160)63-134-107(165)83(127)60-98(161)162)119(177)145-95(59-78-62-133-85-38-23-21-36-82(78)85)113(171)137-87(39-24-26-50-125)108(166)135-67(5)106(164)146-96(64-153)117(175)142-92(54-73-31-16-12-17-32-73)115(173)150-104(71(9)157)123(181)152-102(69(7)155)121(179)144-93(55-74-33-18-13-19-34-74)116(174)149-103(70(8)156)122(180)148-99(65(2)3)118(176)151-101(68(6)154)120(178)138-88(40-25-27-51-126)109(167)139-91(57-76-44-48-80(159)49-45-76)112(170)143-94(58-77-61-132-84-37-22-20-35-81(77)84)114(172)141-89(53-72-29-14-11-15-30-72)111(169)140-90(56-75-42-46-79(158)47-43-75)110(168)136-86(105(128)163)41-28-52-131-124(129)130;3-2(4,5)1(6)7/h11-23,29-38,42-49,61-62,65-71,83,86-96,99-104,132-133,153-159H,10,24-28,39-41,50-60,63-64,125-127H2,1-9H3,(H2,128,163)(H,134,165)(H,135,166)(H,136,168)(H,137,171)(H,138,178)(H,139,167)(H,140,169)(H,141,172)(H,142,175)(H,143,170)(H,144,179)(H,145,177)(H,146,164)(H,147,160)(H,148,180)(H,149,174)(H,150,173)(H,151,176)(H,152,181)(H,161,162)(H4,129,130,131);(H,6,7)/t66-,67-,68+,69+,70+,71+,83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,99-,100-,101-,102-,103-,104-;/m0./s1
InChi Key
BCDKUVHDUAUXLN-YRBILCDWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $196

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    10 mg

    $347

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    25 mg

    $649

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    Product Description

    Caveolin-1 (82-101) amide is a 20-amino acid synthetic peptide fragment corresponding to residues 82-101 of caveolin-1, which is involved in endocytosis and interacts with a variety of receptors and other proteins.1 Caveolin-1 (82-101) (0.8 µmol/kg) reduces aging-induced increases in microvascular leakage and fibrosis, as well as the ratio of phosphorylated-to-unphosphorylated PDGFR and protein-rich tyrosine 2 (Pyk2), in aged mouse heart, kidney, and brain. It also increases left ventricular ejection fraction and fractional shortening and reduces aging-induced isovolumic relaxation time (IVRT) and cardiac hypertrophy in aged mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuppuswamy, D., Chinnakkannu, P., Reese, C., et al. The caveolin-1 scaffolding domain peptide reverses aging-associated deleterious changes in multiple organs. J. Pharmacol. Exp. Ther. 378(1), 1-9 (2021).