Host: HEK293 cells • AA: 19-224 • MW: 23 kDa
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C-Reactive Protein (human, recombinant)

Item No. 37018

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CRP
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg, determined by the LAL endotoxin assay
Source
Recombinant human C-reactive protein expressed in HEK293 cells
Amino Acids
19-224
MW
23 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM Tris, 200 mM sodium chloride, 5 mM calcium chloride, pH 8, 5% trehalose, 5% mannitol, and 0.01% Tween 80
UniProt Accession №
P02741-1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    200 µg

    $383

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    Cayman Chemical
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    Product Description

    C-Reactive protein (CRP) is an acute phase protein and a member of the pentraxin family.1 It is composed of five protomers arranged symmetrically around a central pore and is primarily expressed in, and secreted by, the liver. CRP modulates endothelial function, increases protein levels of intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, stimulates coagulation, mediates uptake of LDL into macrophages, and destabilizes atherosclerotic plaques.1,2,3,4,5 In addition, CRP binds to phosphocholine on microbes in a calcium-dependent manner, acts as a ligand for receptors on phagocytic leukocytes, mediates activation of monocytes and macrophages via IL-6 and other cytokines, and assists in the complement pathway.1,6,7 CRP plasma levels increase in response to acute and chronic inflammatory conditions, and high plasma CRP concentrations are associated with an increased risk for atherosclerosis.1,8 Cayman’s C-Reactive Protein (human, recombinant) protein consists of 206 amino acids, has a calculated molecular weight of 23 kDa, and a predicted N-terminus of Gln19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 26 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Volanakis, J.E. Human C-reactive protein: expression, structure, and function. Mol. Immunol. 38, 189-197 (2001).

    2. Pasceri, V., Willerson, J.T., and Yeh, E.T.H. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102, 2165-2168 (2000).

    3. Tracy, R.P. Inflammation in cardiovascular disease cart, horse, or both? Circulation 97, 2000-2002 (1998).

    4. Zwaka, T.P., Hombach, V., and Torzewski, J. C-reactive protein-mediated low density lipoprotein uptake by macrophages. Implications for atherosclerosis. Circulation 103, 1194-1197 (2001).

    5. de Ferranti, S., and Rifai, N. C-reactive protein and cardiovascular disease: a review of risk prediction and interventions. Clin. Chim. Acta 317, 1-15 (2002).

    6. Marnell, L.L., Mold, C., Volzer, M.A., et al. C-reactive protein binds to Fc g RI in transfected COS cells. J. Immunol. 155, 2185-2193 (1995).

    7. Szalai, A.J., van Ginkel, F.W., Wang, Y., et al. Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component. J. Immunol. 165, 1030-1035 (2000).

    8. Ridker, P.M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369 (2003).