A prodrug form of PF-00835231
Related Products
Active Metabolite(s)
36047PF-00835231
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PF-07304814

Item No. 37026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-1H-indole-2-carboxamide
CAS Number
2468015-78-1
Synonyms
  • Lufotrelvir
Molecular Formula
C24H33N4O9P
Formula Weight
552.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
COC1=C2C(NC(C(N[C@@H](CC(C)C)C(N[C@H](C(COP(O)(O)=O)=O)C[C@H]3C(NCC3)=O)=O)=O)=C2)=CC=C1
InChi Code
InChI=1S/C24H33N4O9P/c1-13(2)9-18(28-24(32)19-11-15-16(26-19)5-4-6-21(15)36-3)23(31)27-17(10-14-7-8-25-22(14)30)20(29)12-37-38(33,34)35/h4-6,11,13-14,17-18,26H,7-10,12H2,1-3H3,(H,25,30)(H,27,31)(H,28,32)(H2,33,34,35)/t14-,17-,18-/m0/s1
InChi Key
FQKALOFOWPDTED-WBAXXEDZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    PF-07304814 is a prodrug form of the severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro), inhibitor PF-00835231 (Item No. 36047).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boras, B., Jones, R.M., Anson, B.J., et al. Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. Nat. Commun. 12(1), 6055 (2021).