An inhibitor of NLRP3 inflammasome activation
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Inflammasome Inhibitor 4b

Item No. 37030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, monosodium salt
CAS Number
2768759-64-2
Molecular Formula
C16H19N2O5S • Na
Formula Weight
374.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
253 nm
SMILES
O=C(NS(=O)(C1=CC(C(C)(O)C)=CO1)=O)[N-]C2=CC(C)=CC(C)=C2.[Na+]
InChi Code
InChI=1S/C16H20N2O5S.Na/c1-10-5-11(2)7-13(6-10)17-15(19)18-24(21,22)14-8-12(9-23-14)16(3,4)20;/h5-9,20H,1-4H3,(H2,17,18,19);/q;+1/p-1
InChi Key
CRCJPDAMPOLGQC-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $119

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    Cayman Chemical
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    Product Description

    Inflammasome inhibitor 4b is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation.1 It inhibits ATP-induced IL-1β release by 98.3% in LPS-primed mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Inflammasome inhibitor 4b (3 and 10 mg/kg) decreases paw swelling and mechanical hyperalgesia in a mouse model of gout induced by monosodium urate crystals.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Narros-Fernández, P., Chioua, M., Petcu, S.A., et al. Synthesis and pharmacological evaluation of new N-sulfonylureas as NLRP3 inflammasome inhibitors: Identification of a hit compound to treat gout. J. Med. Chem. 65(8), 6250-6260 (2022).