An ionizable cationic lipid
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TCL053

Item No. 37045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(((4-(dimethylamino)butanoyl)oxy)methyl)-2-((((Z)-tetradec-9-enoyl)oxy)methyl)propane-1,3-diyl (9Z,9'Z)-bis(tetradec-9-enoate)
CAS Number
2361162-70-9
Molecular Formula
C53H95NO8
Formula Weight
874.3
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
SMILES
O=C(CCCN(C)C)OCC(COC(CCCCCCC/C=C\CCCC)=O)(COC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O
InChi Code
InChI=1S/C53H95NO8/c1-6-9-12-15-18-21-24-27-30-33-36-40-49(55)59-45-53(48-62-52(58)43-39-44-54(4)5,46-60-50(56)41-37-34-31-28-25-22-19-16-13-10-7-2)47-61-51(57)42-38-35-32-29-26-23-20-17-14-11-8-3/h15-20H,6-14,21-48H2,1-5H3/b18-15-,19-16-,20-17-
InChi Key
MJPUTLHISFHJJZ-QMJZYSMNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $129

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    10 mg

    $233

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    25 mg

    $515

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    50 mg

    $901

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    Cayman Chemical
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    Product Description

    TCL053 is an ionizable cationic lipid (pKa = 6.8) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo.1 LNPs containing TCL053 and encapsulating sgRNA targeting the donor site of dystrophin exon 45, in combination with TCL053-containing LNPs encapsulating sgRNA targeting the splicing acceptor site of dystrophin exon 45, restore dystrophin expression in myoblasts differentiated from induced-pluripotent stem (iPS) cells isolated from patients with Duchenne muscular dystrophy (DMD). LNPs containing TCL053 and encapsulating mRNA encoding the Cas9 nuclease, in combination with LNPs containing TCL053 and encapsulating single-guide RNA targeting the Rosa26 locus, have been used to induce CRISPR-mediated gene editing in the mouse gastrocnemius muscle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenjo, E., Hozumi, H., Makita, Y., et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat. Commun. 12(1), 7101 (2021).