VE-Cadherin/CD144 Rabbit Monoclonal Antibody (Clone 012)

VE-cadherin, also known as CD144, is a type II classical cadherin and member of the cadherin superfamily of calcium-dependent cell adhesion molecules.¹ It is composed of an N-terminal signal peptide, a pro-peptide, five extracellular cadherin repeats that bind to homotypic cadherins, a transmembrane domain, and a cytoplasmic tail that interacts with the cytoskeleton. VE-cadherin is endothelial cell-specific and is localized to intracellular junctions where it participates in vascular structure assembly.^2,3,4 An anti-VE-cadherin antibody in combination with an anti-CD31 antibody inhibits tube formation in human umbilical vein endothelial cells (HUVECs).⁵ Knockout of Cdh5, the gene encoding VE-cadherin, in mouse embryonic stem cells prevents the formation of vessel-like structures in 11-day-old embryoid bodies.³ VE-cadherin is overexpressed in melanoma and breast cancer and is positively correlated with poor prognosis.⁶ Cayman's VE-Cadherin/CD144 Rabbit Monoclonal Antibody (Clone 012) can be used for immunohistochemistry (IHC).

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1. Yu, W., Yang, L., Li, T., et al. Cadherin signaling in cancer: Its functions and role as a therapeutic target. Front Oncol. 9, 989 (2019).

2. Lampugnani, M.G., Resnati, M., Raiteri, M., et al. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J. Cell Biol. 118(16), 1511-1522 (1992).

3. Vittet, D., Buchou, T., Schweitzer, A., et al. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc. Natl. Acad. Sci. USA 94(12), 6273-6278 (1997).

4. Breviario, F., Caveda, L., Corada, M., et al. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arterioscler. Thromb. Vasc. Biol. 15(8), 1229-1239 (1995).

5. Matsumura, T., Wolff, K., and Petzelbauer, P. Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J. Immunol. 158(7), 3408-3416 (1997).

6. Bartolomé, R.A., Torres, S., Isern de Val, S., et al. VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers. Oncotarget 8(1), 215-227 (2017).