An ionizable cationic lipidoid
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NT1-O14B

Item No. 37095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
2739805-64-0
Molecular Formula
C40H68N2O4S4
Formula Weight
769.2
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
O=C(OCCSSCCCCCCCCCC)CCN(CCC1=CNC2=C1C=CC=C2)CCC(OCCSSCCCCCCCCCC)=O
InChi Code
InChI=1S/C40H68N2O4S4/c1-3-5-7-9-11-13-15-19-31-47-49-33-29-45-39(43)24-27-42(26-23-36-35-41-38-22-18-17-21-37(36)38)28-25-40(44)46-30-34-50-48-32-20-16-14-12-10-8-6-4-2/h17-18,21-22,35,41H,3-16,19-20,23-34H2,1-2H3
InChi Key
LBQUNMQRWYTNHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 mg

    $42

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    10 mg

    $63

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    25 mg

    $147

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    Cayman Chemical
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    Product Description

    NT1-O14B is a tryptamine-containing ionizable cationic lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and the cationic lipidoid 306-O12B-3 (Item No. 37096) encapsulating antisense oligonucleotides (ASOs) against tau decreases tau brain levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, F., Yang, L., Sun, Z., et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci. Adv. 6(30), eabb4429 (2020).