An anticancer agent
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QN523

Item No. 37123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-8-quinolinyl-2-pyrazinecarboxamide
CAS Number
878581-60-3
Molecular Formula
C14H10N4O
Formula Weight
250.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/ml
λmax
240 nm
SMILES
O=C(C1=NC=CN=C1)NC2=CC=CC3=C2N=CC=C3
InChi Code
InChI=1S/C14H10N4O/c19-14(12-9-15-7-8-16-12)18-11-5-1-3-10-4-2-6-17-13(10)11/h1-9H,(H,18,19)
InChi Key
CYTYVKQBOOTXRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Cayman Chemical
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    Product Description

    QN523 is an anticancer agent.1 It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 µM, respectively). QN523 (0.5 µM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABAA receptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuang, Y., Ye, N., Kyani, A., et al. Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN523 in pancreatic cancer. J. Med. Chem. 65(8), 6133-6156 (2022).