An inhibitor of SPNS2
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SLF1081851 (hydrochloride)

Item No. 37150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-decylphenyl)-1,2,4-oxadiazole-5-propanamine, monohydrochloride
CAS Number
2999629-35-3
Molecular Formula
C21H33N3O • HCl
Formula Weight
380.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
NCCCC1=NC(C2=CC=C(CCCCCCCCCC)C=C2)=NO1.Cl
InChi Code
InChI=1S/C21H33N3O.ClH/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-23-20(25-24-21)12-10-17-22;/h13-16H,2-12,17,22H2,1H3;1H
InChi Key
ZJJXKBLUUGLWDW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $351

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    10 mg

    $578

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    Product Description

    SLF1081851 is an inhibitor of sphingosine-1-phosphate (S1P) transporter (SPNS2).1 It inhibits mouse Spns2 by 67% when used at a concentration of 2 µM. SLF1081851 inhibits S1P export from HeLa cells expressing mouse Spns2 (IC50 = 1.93 µM). In vivo, SLF1081851 (20 mg/kg) decreases blood lymphocyte numbers and plasma S1P levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fritzemeier, R., Foster, D., Peralta, A., et al. Discovery of in vivo active sphingosine-1-phosphate transporter (Spns2) inhibitors. J. Med. Chem. 65(11), 7656-7681 (2022).