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ITGAL/CD11a Chimeric Monoclonal Antibody (Clone hu1124 (Efalizumab))

Item No. 37155

Product Insert (PDF)
Technical Information
Synonyms
  • CD11 Antigen-like Family Member A
  • Integrin subunit αL
  • ITGAL
  • Leukocyte Adhesion Glycoprotein LFA-1 α chain
  • LFA-1A
Immunogen
Recombinant human CD11a
Clone Designation
hu1124 (Efalizumab)
Formulation (Request formulation change)
200 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 0.02% ProClin™ 300
Host
Chimeric Monoclonal Antibody
Isotype
IgG1κ
Applications
FC; block
Species Reactivity
(+) Human
UniProt Accession №
P20701
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    200 µg

    $473

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    Product Description

    CD11a, also known as integrin αL (ITGAL), is a protein subunit of the heterodimeric leukocyte integrin αLβ2.1 It is composed of an extracellular domain that contains an I-domain and a metal-binding domain, which are important for binding, a transmembrane region, and a short cytoplasmic tail.2 CD11a is expressed ubiquitously on the surface of leukocytes as a component of αLβ2, which binds to intracellular adhesion molecule 1-5 (ICAM-1-5), junctional adhesion molecule A (JAM-A), and endothelial cell-specific molecule 1 (ESM-1) to facilitate T cell adhesion and migration during extravasation into the lymph nodes and tissue.3 SNPs in ITGAL are associated with a reduced susceptibility to Behҫet’s disease, a systemic inflammatory disease.4 Cayman’s ITGAL/CD11a Chimeric Monoclonal Antibody (Clone hu1124 (Efalizumab)) was recombinantly generated based on the sequence of the original humanized anti-CD11a antibody hu1124.5 It can be used for flow cytometry (FC).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bednarczyk, M., Stege, H., Grabbe, S., et al. β2 Integrins—multi-functional leukocyte receptors in health and disease. Int. J. Mol. Sci. 21(4), 1402 (2020).

    2. Knight, J.M., Lee, S.-H., Roberts, L., et al. CD11a polymorphisms regulate TH2 cell homing and TH2-related disease. J. Allergy Clin. Immunol. 133(1), 189-197 (2014).

    3. Walling, B.L., and Kim, M. LFA-1 in T cell migration and differentiation. Front. Immunol. 9, 952 (2018).

    4. Park, S.R., Park, K.S., Park, Y.J., et al. CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behçet’s disease in Koreans. Tissue Antigens 84(4), 398-404 (2014).

    5. Bauer, R.J., Dedrick, R.L., White, M.L., et al. Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis. J. Pharmacokinet. Biopharm. 27(4), 397-420 (1999).