A photo cross-linking agent
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DiZPK

Item No. 37191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N6-[[[3-(3-methyl-3H-diazirin-3-yl)propyl]amino]carbonyl]-L-lysine
CAS Number
1337883-32-5
Molecular Formula
C12H23N5O3
Formula Weight
285.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble
SMILES
OC([C@@H](N)CCCCNC(NCCCC1(N=N1)C)=O)=O
InChi Code
InChI=1S/C12H23N5O3/c1-12(16-17-12)6-4-8-15-11(20)14-7-3-2-5-9(13)10(18)19/h9H,2-8,13H2,1H3,(H,18,19)(H2,14,15,20)/t9-/m0/s1
InChi Key
YGUIFRMUMYTGAV-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $79

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    10 mg

    $113

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    Cayman Chemical
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    Product Description

    DiZPK is a photo cross-linking agent.1,2 It contains a diazirine moiety, which, upon UV activation, creates reactive carbenes that form covalent bonds with amino acid side chains and peptide backbones. Incorporation of DiZPK into proteins has been used to map protein-protein interactions in live cells and monitor bacterial defense protein interactions with enteric bacterial pathogens.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Y., Song, H., and Chen, P.R. Genetically encoded photocrosslinkers for identifying and mapping protein-protein interactions in living cells. IUBMB Life 68(11), 879-886 (2016).

    2. Lin, S., Zhang, Z., Xu, H., et al. Site-specific incorporation of photo-cross-linker and bioorthogonal amino acids into enteric bacterial pathogens. J. Am. Chem. Soc. 133(50), 20581-20587 (2011).