An N- and L-type calcium channel inhibitor
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NS 638

Item No. 37193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-1H-benzimidazol-2-amine
CAS Number
150493-34-8
Molecular Formula
C15H11ClF3N3
Formula Weight
325.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): insol
SMILES
FC(F)(C1=CC(N=C(N2CC3=CC=C(C=C3)Cl)N)=C2C=C1)F
InChi Code
InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21)
InChi Key
GXQCVUZORDAARJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $116

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    50 mg

    $513

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    100 mg

    $910

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    Product Description

    NS 638 is an inhibitor of the N-type voltage-gated calcium channel Cav2.2 and CNS L-type calcium channels.1 It inhibits potassium-induced calcium uptake in chick cortical synaptosomes (IC50 = 3.4 µM) and AMPA-induced GABA release from primary chick cortical neurons (IC50 = 4.3 µM), effects that can be blocked by the N-type calcium channel inhibitor ω-conotoxin GVIA (Item No. 24114) but not the L-type calcium channel inhibitor nifedipine (Item No. 11106). It also inhibits potassium-induced calcium level increases in primary chick cerebellar granule cells (IC50 = 3.4 µM), an effect that can be blocked by nifedipine but not ω-conotoxin GVIA. NS 638 (50 mg/kg) reduces infarct volume in a mouse model of focal ischemia induced by middle cerebral artery occlusion (MCAO) but not in a gerbil model of global ischemia induced by bilateral carotid artery occlusion (BCAO).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Møller, A., Christophersen, P., Drejer, J., et al. Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638. Neurol. Res. 17(5), 353-360 (1995).