An ionizable cationic lipid
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LP-01

Item No. 37278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z,12Z-octadecadienoic acid, 3-[4,4-bis(octyloxy)-1-oxobutoxy]-2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]propyl ester
CAS Number
1799316-64-5
Synonyms
  • CIN-16645
Molecular Formula
C50H93NO9
Formula Weight
852.3
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Dichloromethane: SolubleDMF: SolubleDMSO: SolubleEthanol: Soluble
SMILES
CCCCCCCCOC(OCCCCCCCC)CCC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(OCCCN(CC)CC)=O)=O
InChi Code
InChI=1S/C50H93NO9/c1-6-11-14-17-20-21-22-23-24-25-26-27-28-29-32-36-47(52)58-43-46(45-60-50(54)57-42-35-39-51(9-4)10-5)44-59-48(53)37-38-49(55-40-33-30-18-15-12-7-2)56-41-34-31-19-16-13-8-3/h20-21,23-24,46,49H,6-19,22,25-45H2,1-5H3/b21-20-,24-23-
InChi Key
CHTXXFZHKGGQGX-IFLFXUNCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $115

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    10 mg

    $173

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    25 mg

    $230

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    100 mg

    $690

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    Cayman Chemical
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    Product Description

    LP-01 is an ionizable cationic lipid (pKa = ~6.1).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of single-guide RNA (sgRNA) and mRNA in vitro and in vivo.1,2 LNPs containing LP-01 and encapsulating both Cas9 mRNA and modified sgRNA for the transport protein transthyretin (Ttr) induce gene editing in liver cells in mice in a dose-dependent manner resulting in reduced serum Ttr levels for at least 12 months.1 Subretinal administration of LNPs containing LP-01 and encapsulating both Cas9 mRNA and sgRNA targeting the loxP stop codon induce retinal gene editing in Ai9 mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Finn, J.D., Smith, A.R., Patel, M.C., et al. A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing. Cell Rep. 22(9), 2227-2235 (2018).

    2. Eygeris, Y., Henderson, M.I., Curtis, A.G., et al. Preformed vesicle approach to LNP manufacturing enhances retinal mRNA delivery. Small e2400815 (2024).