An ionizable cationic lipid
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CL4H6

Item No. 37279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-octadecenoic acid, 1,1′-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester
CAS Number
2256087-35-9
Molecular Formula
C59H113NO5
Formula Weight
916.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CCCN(CCC)CCCCC(O)(CCCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O
InChi Code
InChI=1S/C59H113NO5/c1-5-9-11-13-15-17-19-21-23-25-27-29-31-33-39-47-57(61)64-55-45-37-35-41-49-59(63,51-43-44-54-60(52-7-3)53-8-4)50-42-36-38-46-56-65-58(62)48-40-34-32-30-28-26-24-22-20-18-16-14-12-10-6-2/h21-24,63H,5-20,25-56H2,1-4H3/b23-21-,24-22-
InChi Key
ZFFZMGJMZGAGMF-SXAUZNKPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

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    10 mg

    $260

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    Product Description

    CL4H6 is an ionizable cationic lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA for use in vivo.1 LNPs containing CL4H6 and encapsulating siRNA targeting mRNA encoding Factor VII decrease hepatic levels of Factor VII in mice. LNPs containing CL4H6 and encapsulating a reporter protein selectively accumulate in the liver, spleen, and tumors over the lungs and kidneys, as well as selectively accumulate in tumor-associated macrophages (TAMs) over tumor cells, neutrophils, and other leukocytes, in an OS-RC-2 renal cancer mouse xenograft model after intravenous administration.2 LNPs containing CL4H6 and encapsulating siRNAs targeting mRNA encoding Stat3 and Hif-1α increase the levels of M1 macrophages in the tumor microenvironment and decrease tumor volume in the same model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, Y., Hashiba, K., Sasaki, K., et al. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo. J. Control. Release 295, 140-152 (2019).

    2. Shobaki, N., Sato, Y., Suzuki, Y., et al. Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy. J. Control. Release 325, 235-248 (2020).