A TRPA1 antagonist
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AM0902

Item No. 37290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
CAS Number
1883711-97-4
Molecular Formula
C17H15ClN6O2
Formula Weight
370.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
214 nm
SMILES
O=C1C2=C(N=CN2C)N=CN1CC3=NC(CCC4=CC=C(Cl)C=C4)=NO3
InChi Code
InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3
InChi Key
AWJBWNUUODWOKQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $98

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    10 mg

    $163

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    Product Description

    AM0902 is a transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 = 0.131 µM for the human receptor in a calcium mobilization assay).1 It is selective for human TRPA1 over human transient receptor potential vanilloid 1 (TRPV1) and TRPV4, rat TRPV1, TRPV3, and transient receptor potential melastatin 8 (TRPM8), and a panel of 40 additional targets at 10 µM. In vivo, AM0902 (10 and 30 mg/kg) reduces the number of tail flinches induced by the TRPA1 agonist allyl isothiocyanate (AITC) in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schenkel, L.B., Olivieri, P.R., Boezio, A.A., et al. Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J. Med. Chem. 59(6), 2794-2809 (2016).