An activator of Kv7.2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ICA 110381

Item No. 37294

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-N-(6-chloro-3-pyridinyl)-benzamide
CAS Number
325457-99-6
Molecular Formula
C12H8Cl2N2O
Formula Weight
267.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
268 nm
SMILES
O=C(C1=CC=C(C=C1)Cl)NC2=CN=C(Cl)C=C2
InChi Code
InChI=1S/C12H8Cl2N2O/c13-9-3-1-8(2-4-9)12(17)16-10-5-6-11(14)15-7-10/h1-7H,(H,16,17)
InChi Key
FOYOGIUAMYSVIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $55

    Add

    10 mg

    $105

    Add

    25 mg

    $235

    Add

    50 mg

    $440

    Add
    Product Description

    ICA 110381 is an activator of voltage-gated potassium channel Kv7.2.1 It induces rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells (EC50 = 0.38 µM for the human channel). ICA 110381 also inhibits rubidium efflux from CHO cells expressing Kv7.1 (EC50 = 15 µM for the human channel). It reduces seizure number and increases the current threshold for seizure induction by amygdala-kindling in rats when administered at a dose of 30 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amato, G., Roeloffs, R., Rigdon, G.C., et al. N-Pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med. Chem. Lett. 2(6), 481-484 (2011).

    2. Boehlen, A., Schwake, M., Dost, R., et al. The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br. J. Pharmacol. 168(5), 1182-1200 (2012).