An activator of Kv7.2
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ICA 110381

Item No. 37294

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-N-(6-chloro-3-pyridinyl)-benzamide
CAS Number
325457-99-6
Molecular Formula
C12H8Cl2N2O
Formula Weight
267.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
268 nm
SMILES
O=C(C1=CC=C(C=C1)Cl)NC2=CN=C(Cl)C=C2
InChi Code
InChI=1S/C12H8Cl2N2O/c13-9-3-1-8(2-4-9)12(17)16-10-5-6-11(14)15-7-10/h1-7H,(H,16,17)
InChi Key
FOYOGIUAMYSVIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $105

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    25 mg

    $235

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    50 mg

    $440

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    Product Description

    ICA 110381 is an activator of voltage-gated potassium channel Kv7.2.1 It induces rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells (EC50 = 0.38 µM for the human channel). ICA 110381 also inhibits rubidium efflux from CHO cells expressing Kv7.1 (EC50 = 15 µM for the human channel). It reduces seizure number and increases the current threshold for seizure induction by amygdala-kindling in rats when administered at a dose of 30 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amato, G., Roeloffs, R., Rigdon, G.C., et al. N-Pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med. Chem. Lett. 2(6), 481-484 (2011).

    2. Boehlen, A., Schwake, M., Dost, R., et al. The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br. J. Pharmacol. 168(5), 1182-1200 (2012).