An inducer of chaperone-mediated autophagy
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CA77.1

Item No. 37300

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(6-chloro-2-quinoxalinyl)phenyl]-acetamide
CAS Number
2412270-22-3
Molecular Formula
C16H12ClN3O
Formula Weight
297.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/ml
λmax
214, 269, 302, 363 nm
SMILES
O=C(C)NC1=CC=C(C2=NC3=CC=C(C=C3N=C2)Cl)C=C1
InChi Code
InChI=1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)
InChi Key
ZQXMPDVGBWOTBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $85

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    10 mg

    $156

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    25 mg

    $316

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    Product Description

    CA77.1 is an inducer of chaperone-mediated autophagy (CMA).1 It induces the formation of autophagic lysosomes in NIH3T3 cells expressing a CMA reporter when used at concentrations of 10, 20, and 30 µM. CA77.1 (20 µM) induces autophagic flux in NIH3T3 cells. In vivo, CA77.1 (30 mg/kg) reduces locomotor hyperactivity to control levels and the number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex in a PS19 transgenic mouse model of Alzheimer's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bourdenx, M., Martin-Segura, A., Scrivo, A., et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell 184(10), 2696-2714.e2625 (2021).