A Bax activator
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BTSA1

Item No. 37305

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione, 4-[2-(2-thiazolyl)hydrazone]
CAS Number
314761-14-3
Synonyms
  • Bax Trigger Site Activator 1
Molecular Formula
C21H14N6OS2
Formula Weight
430.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 2 mg/mlEthanol: Slightly soluble
λmax
249 nm
SMILES
O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)C1=NNC5=NC=CS5
InChi Code
InChI=1S/C21H14N6OS2/c28-19-18(24-25-20-22-11-12-29-20)17(15-9-5-2-6-10-15)26-27(19)21-23-16(13-30-21)14-7-3-1-4-8-14/h1-13H,(H,22,25)
InChi Key
KYVZVVOQWWCVPP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    BTSA1 is an activator of Bax.1 It binds to the Bax N-terminal activation site, also known as the trigger site (IC50 = 250 nM), and induces Bax translocation membrane permeabilization in liposomes when used at concentrations ranging from 100 to 400 nM. BTSA1 (0.1-1 µM) induces apoptosis in various human and mouse acute myeloid leukemia (AML) cell lines. In vivo, BTSA (10 mg/kg) reduces bone marrow infiltration and promotes apoptosis in bone marrow infiltrates in a MOLM-13 AML mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reyna, D.E., Garner, T.P., Lopez, A., et al. Direct activation of BAX by BTSA1 overcomes apoptosis resistance in acute myeloid leukemia. Cancer Cell 32(4), 490-505 (2017).