An sPLA2 inhibitor
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MDK8582

Item No. 37307

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-amino-2-oxoethoxy)-2-ethyl-α-oxo-1-(phenylmethyl)-1H-indole-3-acetamide
CAS Number
185298-58-2
Synonyms
  • hnps-PLA Inhibitor
  • hnps-Phospholipase A Inhibitor
  • Human Nonpancreatic Secretory Phospholipase A Inhibitor
  • Human Nonpancreatic Secretory PLA Inhibitor
Molecular Formula
C21H21N3O4
Formula Weight
379.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C(C1=C(CC)N(CC2=CC=CC=C2)C3=C1C(OCC(N)=O)=CC=C3)=O)N
InChi Code
InChI=1S/C21H21N3O4/c1-2-14-19(20(26)21(23)27)18-15(9-6-10-16(18)28-12-17(22)25)24(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,25)(H2,23,27)
InChi Key
HJPAGOZVVSAGKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $39

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    5 mg

    $126

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    10 mg

    $231

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    25 mg

    $385

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    Product Description

    MDK8582 is an inhibitor of secretory phospholipase A2 (sPLA2; IC50 = 0.124 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bernard, P., Pintore, M., Berthon, J.Y., et al. A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2. Eur. J. Med. Chem. 36(1), 1-19 (2001).