A positive allosteric modulator of KCa2.2/SK2 and KCa2.3/SK3
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NS 13001

Item No. 37317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
CAS Number
1063331-94-1
Molecular Formula
C17H16ClN7
Formula Weight
353.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
269, 303 nm
SMILES
ClC1=CC=C(C=C1)NC2=C(C3=NC(N4N=C(C=C4C)C)=N2)N=CN3C
InChi Code
InChI=1S/C17H16ClN7/c1-10-8-11(2)25(23-10)17-21-15(14-16(22-17)24(3)9-19-14)20-13-6-4-12(18)5-7-13/h4-9H,1-3H3,(H,20,21,22)
InChi Key
DVQOPNIPUIOXHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $126

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    10 mg

    $231

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    25 mg

    $385

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    Product Description

    NS 13001 is a positive allosteric modulator for small-conductance calcium-activated potassium channel 2 (KCa2.2/SK2) and KCa2.3/SK3.1 It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human KCa2.2/SK2 or KCa2.3/SK3 (EC50s = 1.8 and 0.14 µM, respectively). Oral administration of NS 13001 (30 mg/kg per day) improves sensorimotor deficits in the beam walk test and increases the latency to fall in the rotarod test in a SCA2-58Q transgenic mouse model of neuromuscular degeneration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kasumu, A.W., Hougaard, C., Rode, F., et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem. Biol. 19(10), 1340-1353 (2012).