An isoxazoline ectoparasiticide
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Sarolaner

Item No. 37321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[5′-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1′(3′H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)-ethanone
CAS Number
1398609-39-6
Synonyms
  • PF-6450567
Molecular Formula
C23H18Cl2F4N2O5S
Formula Weight
581.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly soluble
λmax
261 nm
SMILES
CS(CC(N1CC2(C1)C3=CC=C(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(C(Cl)=C5)F)C4)C=C3CO2)=O)(=O)=O
InChi Code
InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
InChi Key
FLEFKKUZMDEUIP-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Sarolaner is an isoxazoline ectoparasiticide.1 It inhibits GABA-induced chloride currents in CHO-K1 cells expressing either the gene for susceptible C. felis flea resistance-to-dieldrin subunits containing alanine at residue 285 (CfRDL-A285; IC50 = 135 nM) or the gene for CfRDL subunits containing the alanine-to-serine resistance mutation (CfRDL-S285; IC50 = 136 nM). It induces mortality in C. felis fleas (LC80 = 0.3 µg/ml) and O. turicata soft ticks (LC100 = 0.003 µg/ml). Sarolaner (2.5 mg/kg) eliminates live C. felis fleas, as well as R. sanguineus, I. ricinus, and D. reticulatus ticks, on dogs after 48 hours and reduces the number of fleas and ticks for at least 35 days. Formulations containing sarolaner have been used in the treatment and control of flea and tick infestations in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McTier, T.L., Chubb, N., Curtis, M.P., et al. Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Vet. Parasitol. 222, 3-11 (2016).