An imidazopyridine amide antibiotic
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Q203

Item No. 37323

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]-imidazo[1,2-a]pyridine-3-carboxamide
CAS Number
1334719-95-7
Synonyms
  • Telacebec
Molecular Formula
C29H28ClF3N4O2
Formula Weight
557.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 14 mg/mlEthanol: Slightly soluble
λmax
257 nm
SMILES
O=C(C1=C(CC)N=C2C=CC(Cl)=CN21)NCC3=CC=C(N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)C=C3
InChi Code
InChI=1S/C29H28ClF3N4O2/c1-2-25-27(37-18-22(30)7-12-26(37)35-25)28(38)34-17-19-3-8-23(9-4-19)36-15-13-21(14-16-36)20-5-10-24(11-6-20)39-29(31,32)33/h3-12,18,21H,2,13-17H2,1H3,(H,34,38)
InChi Key
OJICYBSWSZGRFB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Q203 is an imidazopyridine amide antibiotic.1 It is active against M. tuberculosis and M. ulcerans (MIC50s = 2.7 and 0.86 nM, respectively).1,2 Q203 binds to the oxidation site on mitochondrial complex III, also known as cytochrome bc1 complex, and disrupts ATP synthesis in M. tuberculosis (IC50 = 1.1 nM).1 It reduces bacterial load, as well as the number of lung colony forming units (CFUs) and granulomatous foci in a mouse model of M. tuberculosis infection when administered at a dose of 10 mg/kg for three days.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pethe, K., Bifani, P., Jang, J., et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 19(9), 1157-1160 (2013).

    2. Scherr, N., Bieri, R., Thomas, S.S., et al. Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer. Nat. Commun. 9(1), 5370 (2018).