A PKM2 activator
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ML-202

Item No. 37326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2′,3′:4,5]pyrrolo[2,3-d]pyridazin-5-one
CAS Number
1221186-52-2
Molecular Formula
C18H17N3O3S2
Formula Weight
387.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
270, 305 nm
SMILES
O=C1C2=C(C3=C(N2C)C=C(S(C)=O)S3)C=NN1CC4=CC(OC)=CC=C4
InChi Code
InChI=1S/C18H17N3O3S2/c1-20-14-8-15(26(3)23)25-17(14)13-9-19-21(18(22)16(13)20)10-11-5-4-6-12(7-11)24-2/h4-9H,10H2,1-3H3
InChi Key
MORBXZMIXGYQDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $200

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    10 mg

    $377

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    25 mg

    $836

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    Product Description

    ML-202 is an activator of pyruvate kinase M2 (PKM2).1 It induces PMK2 activation in a cell-free assay with a 50% activation concentration (AC50) value of 73 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, J., Boxer, M.B., Heiden, M.G.V., et al. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg. Med. Chem. Lett. 20(11), 3387-3393 (2010).