An irreversible inhibitor of MPO
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Verdiperstat

Item No. 37333

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,5-tetrahydro-1-[2-(1-methylethoxy)ethyl]-2-thioxo-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS Number
890655-80-8
Synonyms
  • AZD 3241
  • BHV 3421
Molecular Formula
C11H15N3O2S
Formula Weight
253.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/ml
λmax
227, 259, 292 nm
SMILES
O=C1NC(N(CCOC(C)C)C2=C1NC=C2)=S
InChi Code
InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)
InChi Key
FVJCUZCRPIMVLB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $46

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    10 mg

    $73

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    25 mg

    $158

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    50 mg

    $270

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    Product Description

    Verdiperstat is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 630 nM), a redox enzyme involved in oxidative stress.1 It is selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all).2 Oral administration of verdiperstat (180 µmol/kg) reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy, a neurological disorder characterized by motor neuron degeneration and α-synuclein aggregation in the brain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnström, P., Bergman, L., Varnäs, K., et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl. Med. Biol. 42(6), 555-560 (2015).

    2. Stefanova, N., Georgievska, B., Eriksson, H., et al. Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model. Neurotox. Res. 21(4), 393-404 (2012).