A TNF inhibitor
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UCB 9260

Item No. 37336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-1H-benzimidazole-2-methanol
CAS Number
1515888-53-5
Molecular Formula
C26H25N5O
Formula Weight
423.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: Slightly soluble
SMILES
OC(C1=NC2=C(N1CC3=CC(C)=CC=C3C)C=C(C4=CN(C)N=C4)C=C2)C5=CC=NC=C5
InChi Code
InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3
InChi Key
RZGFWGNCSYUEPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

    $225

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    25 mg

    $532

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    50 mg

    $1,003

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    Cayman Chemical
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    Product Description

    UCB 9260 is a TNF inhibitor.1 It binds to trimeric TNF (Kd = 13.8 nM) and selectively increases the thermal stability of the TNF trimer over 10 other TNF superfamily members at 100 µM. UCB 9260 inhibits TNF-induced NF-κB activity in a reporter assay using HEK293 cells and TNF-induced cytotoxicity in L-929 fibroblasts (IC50s = 202 and 116 nM, respectively). In vivo, UCB 9260 (30-300 mg/kg, p.o.) reduces TNF-induced peritoneal neutrophil recruitment in mice. Intraperitoneal administration of UCB 9260 (150 mg/kg) decreases disease severity in a mouse model of collagen antibody-induced arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Connell, J., Porter, J., Kroeplien, B., et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat. Commun. 10(1), 5795 (2019).