An antiviral agent
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Pocapavir

Item No. 37349

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2-chloro-4-methoxyphenoxy)methyl]-4-[(2,6-dichlorophenoxy)methyl]-benzene
CAS Number
146949-21-5
Synonyms
  • SCH 48973
  • V-073
Molecular Formula
C21H17Cl3O3
Formula Weight
423.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC=CC(Cl)=C1OCC2=CC=C(COC3=CC=C(C=C3Cl)OC)C=C2
InChi Code
InChI=1S/C21H17Cl3O3/c1-25-16-9-10-20(19(24)11-16)26-12-14-5-7-15(8-6-14)13-27-21-17(22)3-2-4-18(21)23/h2-11H,12-13H2,1H3
InChi Key
XXMDDBVNWRWNCW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $140

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    25 mg

    $257

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    50 mg

    $476

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    Cayman Chemical
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    Product Description

    Pocapavir is an antiviral agent.1 It reduces viral replication in HeLa cells infected with poliovirus type 2, group A9 coxsackievirus, or Echovirus type 4, -6, or -11 (IC50s = 0.08, 0.09, 0.11, 0.03, and 0.02 µg/ml, respectively). It also inhibits viral replication of 154 clinical enterovirus isolates in infected HeLa cells (mean IC50 = 0.9 µg/ml). In vivo, pocapavir (3, 10, and 20 mg/kg) increases survival in poliovirus type 2-infected mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buontempo, P.J., Cox, S., Wright-Minogue, J., et al. SCH 48973: A potent, broad-spectrum, antienterovirus compound. Antimicrob Agents Chemother. 41(6), 1220-1225 (1997).