An anticancer agent
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CAY10792

Item No. 37353

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9β,13α,14β,20α)-3-hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester
CAS Number
2361009-68-7
Molecular Formula
C35H44ClN3O6
Formula Weight
638.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(OCCCN4C(Cl)=NC([N+]([O-])=O)=C4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
InChi Code
InChI=1S/C35H44ClN3O6/c1-21-22-8-9-25-33(4,23(22)18-24(40)28(21)41)13-15-35(6)26-19-32(3,11-10-31(26,2)12-14-34(25,35)5)29(42)45-17-7-16-38-20-27(39(43)44)37-30(38)36/h8-9,18,20,26,41H,7,10-17,19H2,1-6H3/t26-,31-,32-,33+,34-,35+/m1/s1
InChi Key
QHBZROOTFSFIMF-JVIXZCSZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $97

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    5 mg

    $412

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    10 mg

    $724

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    Cayman Chemical
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    Product Description

    CAY10792 is an anticancer agent.1 It binds to heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) in cell-free assays. CAY10792 inhibits the growth of A549, HCT116, U2OS, and MDA-MB-231 cancer cells (IC50s = 0.54, 0.59, 0.57, and 0.57 µM, respectively) but not A549 cells overexpressing Hsp90, Cdc37, or Hsp90 and Cdc37 (IC50s = >100 µM for all). It induces cell cycle arrest at the G0/G1 phase and apoptosis in A549 lung cancer cells when used at a concentration of 0.8 µM. In vivo, CAY10792 (0.5 and 1 mg/kg) reduces tumor weight in an A549 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, N., Xu, M., Zhang, L., et al. Discovery of novel celastrol-imidazole derivatives with anticancer activity in vitro and in vivo. J. Med. Chem. 65(6), 4578-4589 (2022).