An aurone with diverse biological activities
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Hispidol

Item No. 37373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-hydroxy-2Z-[(4-hydroxyphenyl)methylene]-3(2H)-benzofuranone
CAS Number
5786-54-9
Synonyms
  • 4′,6-Dihydroxyaurone
  • (Z)-Hispidol
Molecular Formula
C15H10O4
Formula Weight
254.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
255, 380 nm
SMILES
O=C1C2=CC=C(O)C=C2O/C1=C\C3=CC=C(C=C3)O
InChi Code
InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)7-14-15(18)12-6-5-11(17)8-13(12)19-14/h1-8,16-17H/b14-7-
InChi Key
KEZLDSPIRVZOKZ-AUWJEWJLSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $422

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    Product Description

    Hispidol is an aurone originally isolated from soybeans that has diverse biological activities.1,2,3,4 It is an inhibitor of tyrosinase, monoamine oxidase A (MAO-A), and MAO-B (IC50s= 38.4, 0.26, and 2.45 µM, respectively).1,3 Hispidol (50 µM) increases catalase and superoxide dismutase (SOD) activity in cell-free assays, as well as decreases intracellular reactive oxygen species (ROS) in, and increases the lifespan of, C. elegans.4 It decreases immobility time in forced swim and tail suspension tests in mice when administered at a dose of 2, 5, and 15 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okombi, S., Rival, D., Bonnet, S., et al. Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes. J. Med. Chem. 49(1), 329-333 (2006).

    2. Wong, E. Occurrence and biosynthesis of 4′,6-dihydroxyaurone in soybean. Phytochem. 5(3), 463-467 (1966).

    3. Oh, J.M., Lee, H.-S., Baek, S.C., et al. Antidepressant-like activities of hispidol and decursin in mice and analysis of neurotransmitter monoamines. Neurochem. Res. 45(8), 1930-1940 (2020).

    4. Lim, H.J., Han, Y.T., Ahn, J.-H., et al. Longevity effects of hispidol in Caenorhabditis elegans. Biofactors 46(6), 1041-1048 (2020).