A clickable Cdc25 inhibitor
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M2N12

Item No. 37391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-7-[[[1-[(4-methylphenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-5,8-quinolinedione
CAS Number
2376577-06-7
Molecular Formula
C20H16ClN5O2
Formula Weight
393.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C1C(Cl)=C(C(C2=NC=CC=C12)=O)NCC3=CN(CC4=CC=C(C)C=C4)N=N3
InChi Code
InChI=1S/C20H16ClN5O2/c1-12-4-6-13(7-5-12)10-26-11-14(24-25-26)9-23-18-16(21)19(27)15-3-2-8-22-17(15)20(18)28/h2-8,11,23H,9-10H2,1H3
InChi Key
BDBIMDYALUJAPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $91

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    5 mg

    $406

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    10 mg

    $722

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    Cayman Chemical
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    Product Description

    M2N12 is a clickable inhibitor of cell division cycle 25 (Cdc25; IC50s = 0.53, 1.39, and 0.09 µM for Cdc25A, Cdc25B, and Cdc25C, respectively).1 It is composed of a naphthoquinone derivative functionalized with a clickable cyclic azide group. M2N12 inhibits the proliferation of A549 lung cancer and MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 3.92, 4.63, and 4.71 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jing, L., Wu, G., Hao, X., et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur. J. Med. Chem. 183, 111696 (2019).