A clickable Cdc25 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

M2N12

Item No. 37391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-7-[[[1-[(4-methylphenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-5,8-quinolinedione
CAS Number
2376577-06-7
Molecular Formula
C20H16ClN5O2
Formula Weight
393.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C1C(Cl)=C(C(C2=NC=CC=C12)=O)NCC3=CN(CC4=CC=C(C)C=C4)N=N3
InChi Code
InChI=1S/C20H16ClN5O2/c1-12-4-6-13(7-5-12)10-26-11-14(24-25-26)9-23-18-16(21)19(27)15-3-2-8-22-17(15)20(18)28/h2-8,11,23H,9-10H2,1H3
InChi Key
BDBIMDYALUJAPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $91

    Add

    5 mg

    $406

    Add

    10 mg

    $722

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    M2N12 is a clickable inhibitor of cell division cycle 25 (Cdc25; IC50s = 0.53, 1.39, and 0.09 µM for Cdc25A, Cdc25B, and Cdc25C, respectively).1 It is composed of a naphthoquinone derivative functionalized with a clickable cyclic azide group. M2N12 inhibits the proliferation of A549 lung cancer and MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 3.92, 4.63, and 4.71 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jing, L., Wu, G., Hao, X., et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur. J. Med. Chem. 183, 111696 (2019).