A CP4H1 inhibitor
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pythiDC

Item No. 37392

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(5-carboxy-2-thiazolyl)-3-pyridinecarboxylic acid
CAS Number
1821370-71-1
Molecular Formula
C10H6N2O4S
Formula Weight
250.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solublePBS (pH 7.2): Slightly soluble
λmax
321 nm
SMILES
O=C(O)C1=CC=C(C2=NC=C(C(O)=O)S2)N=C1
InChi Code
InChI=1S/C10H6N2O4S/c13-9(14)5-1-2-6(11-3-5)8-12-4-7(17-8)10(15)16/h1-4H,(H,13,14)(H,15,16)
InChi Key
ISYUGJYTQIZJHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $51

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    5 mg

    $152

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    10 mg

    $279

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    25 mg

    $505

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    Product Description

    pythiDC is an inhibitor of collagen prolyl 4-hydroxylase (CP4H) containing the α(I) isoform (CP4H1; IC50 = 4 µM).1 It is selective for CP4H1 over hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vasta, J.D., Andersen, K.A., Deck, K.M., et al. Selective inhibition of collagen prolyl 4-hydroxylase in human cells. ACS Chem. Biol. 11(1), 193-199 (2016).