A modulator of HIF-2α
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M1001

Item No. 37393

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(1-pyrrolidinyl)phenyl]-1,2-benzisothiazol-3-amine, 1,1-dioxide
CAS Number
874590-32-6
Molecular Formula
C17H17N3O2S
Formula Weight
327.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/ml
λmax
210, 255 nm
SMILES
O=S1(N=C(C2=C1C=CC=C2)NC3=C(N4CCCC4)C=CC=C3)=O
InChi Code
InChI=1S/C17H17N3O2S/c21-23(22)16-10-4-1-7-13(16)17(19-23)18-14-8-2-3-9-15(14)20-11-5-6-12-20/h1-4,7-10H,5-6,11-12H2,(H,18,19)
InChi Key
LONXCUOJVJLTIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $179

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    10 mg

    $315

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    25 mg

    $541

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    Product Description

    M1001 is a modulator of hypoxia-inducible factor-2α (HIF-2α).1 It stabilizes the aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-2α protein-protein interaction and promotes the gene expression of HIF-2α targets VEGF-A, CCND1, SLC2A1, and NDRG1, in 786-O cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, D., Su, X., Lu, J., et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol. 15(4), 367-376 (2019).