A neuronal nAChR agonist
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NS 3861

Item No. 37406

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3-bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene
CAS Number
216853-59-7
Molecular Formula
C12H14BrNS
Formula Weight
284.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CN1C2CC(C3=C(Br)C=CS3)=CC1CC2
InChi Code
InChI=1S/C12H14BrNS/c1-14-9-2-3-10(14)7-8(6-9)12-11(13)4-5-15-12/h4-6,9-10H,2-3,7H2,1H3
InChi Key
ZJCNRVHZJADROC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $355

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    Product Description

    NS 3861 is a neuronal nicotinic acetylcholine receptor (nAChR) agonist.1 It induces inward currents in patch-clamp assays using X. laevis oocytes expressing recombinant human α3β2- or α3β4 subunit-containing nAChR receptors (EC50s = 1.6 and 1 µM, respectively). In vivo, NS 3861 (0.1 mg/kg) increases the number of fecal pellets expelled in mice exposed to long-term, but not short-term, morphine injections.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harpsøe, K., Hald, H., Timmermann, D.B., et al. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. The Journal of Biological Chemisty 288(4), 2559-2570 (2013).

    2. Gade, A.R., Kang, M., Khan, F., et al. Enhanced sensitivity of α3β4 nicotinic receptors in enteric neurons after long-term morphine: Implication for opioid-induced constipation. J. Pharmacol. Exp. Ther. 357(3), 520-528 (2016).