A peptide inhibitor of the PD-1-PD-L1 protein-protein interaction
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TPP-1 (hydrochloride)

Item No. 37410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-L-lysine, monohydrochloride
Synonyms
  • Targeting PD-L1 Peptide
Molecular Formula
C107H150N34O32S2 • HCl
Formula Weight
2525.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
282 nm
SMILES
O=C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CS[H])C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](CS[H])C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N8CCC[C@H]8C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)[C@H](CO)N[H].Cl
InChi Code
InChI=1S/C107H150N34O32S2.ClH/c1-53(125-94(161)70(33-54-19-23-59(146)24-20-54)131-93(160)68(27-28-82(110)148)127-85(151)44-121-89(156)63(109)46-142)88(155)137-78(49-145)100(167)132-71(34-55-21-25-60(147)26-22-55)95(162)135-74(37-58-41-115-52-124-58)98(165)140-80(51-175)102(169)134-73(36-57-40-119-65-14-5-3-12-62(57)65)97(164)139-79(50-174)101(168)133-72(35-56-39-118-64-13-4-2-11-61(56)64)96(163)129-67(17-9-31-117-107(113)114)92(159)136-75(38-87(153)154)104(171)141-32-10-18-81(141)103(170)123-45-86(152)126-66(16-8-30-116-106(111)112)91(158)138-76(47-143)90(157)122-42-83(149)120-43-84(150)128-77(48-144)99(166)130-69(105(172)173)15-6-7-29-108;/h2-5,11-14,19-26,39-41,52-53,63,66-81,118-119,142-147,174-175H,6-10,15-18,27-38,42-51,108-109H2,1H3,(H2,110,148)(H,115,124)(H,120,149)(H,121,156)(H,122,157)(H,123,170)(H,125,161)(H,126,152)(H,127,151)(H,128,150)(H,129,163)(H,130,166)(H,131,160)(H,132,167)(H,133,168)(H,134,169)(H,135,162)(H,136,159)(H,137,155)(H,138,158)(H,139,164)(H,140,165)(H,153,154)(H,172,173)(H4,111,112,116)(H4,113,114,117);1H/t53-,63-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-;/m0./s1
InChi Key
DTVJLSGONKKSLF-ZJWGRDAKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

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    10 mg

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    25 mg

    $448

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    Product Description

    TPP-1 is a peptide inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).1 It binds to PD-L1 in a cell-free assay (Kd = 94.67 nM). TPP-1 (20 µM) reverses PD-L1-induced decreases in IFN-γ levels in anti-CD3-induced isolated human CD4+ T cells. It reduces tumor volume in a mouse xenograft model using HL-60 leukemia cells co-cultured with anti-CD3-activated isolated human CD4+ T cells prior to implantation when administered at a dose of 4 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, C., Zhang, N., Zhou, J., et al. Peptide blocking of PD-1/PD-L1 interaction for cancer immunotherapy. Cancer Immunol. Res. 6(2), 178-188 (2018).