An activator of mechanosensitive K2P channels
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BL 1249

Item No. 37426

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,7,8-tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
CAS Number
18200-13-0
Molecular Formula
C17H17N5
Formula Weight
291.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
C1(C2=C(NC3=CC=CC4=C3CCCC4)C=CC=C2)=NN=NN1
InChi Code
InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
InChi Key
YYNRZIFBTOUICE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

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    10 mg

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    Product Description

    BL 1249 is an activator of mechanosensitive two-pore domain potassium channels (K2P).1 It selectively induces currents in Xenopus oocytes expressing K2P2.1/TREK-1 or K2P10.1/TREK-2 over Xenopus oocytes expressing K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P18.1/TRESK, K2P13.1/THIK1, or K2P1.1/TWIK-1 at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pope, L., Arrigoni, C., Lou, H., et al. Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem. Neurosci. 9(12), 3153-3165 (2018).