An inhibitor of GlyT1a
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LY2365109 (hydrochloride)

Item No. 37427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-glycine, monohydrochloride
CAS Number
1779796-27-8
Molecular Formula
C22H27NO5 • HCl
Formula Weight
421.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble
SMILES
O=C(CN(CCOC1=CC=C(C2=CC3=C(OCO3)C=C2)C=C1C(C)(C)C)C)O.Cl
InChi Code
InChI=1S/C22H27NO5.ClH/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25;/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25);1H
InChi Key
ZQVOAGQZHDAFRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $112

    Add

    10 mg

    $179

    Add

    25 mg

    $279

    Add

    50 mg

    $501

    Add
    Product Description

    LY2365109 is an inhibitor of glycine transporter 1a (GlyT1a; IC50 = 15.8 nM in BE2-C cells expressing the human transporter).1 It is selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter). LY2365109 (10 mg/kg) induces locomotor hyperactivity, impaired gait, compulsive walking, and labored breathing, as well as impairs the ability to stand, in rats.1 It also prevents maximal electroshock-induced acute seizures in mice and decreases the number of seizures in an electroshock-induced rat model of chronic epilepsy when administered at doses of 30 and 10 mg/kg, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perry, K.W., Falcone, J.F., Fell, M.J., et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology 55(5), 743-754 (2008).

    2. Shen, H.-Y., van Vliet, E.A., Bright, K.-A., et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology 99, 554-565 (2015).