An inhibitor of Notch ternary complex formation and an active metabolite of IMR-1
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Parent Compound(s)
27920IMR-1
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IMR-1A

Item No. 37432

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid
CAS Number
331862-41-0
Molecular Formula
C13H11NO5S2
Formula Weight
325.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/ml
λmax
393 nm
SMILES
O=C(COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC)O
InChi Code
InChI=1S/C13H11NO5S2/c1-18-9-4-7(2-3-8(9)19-6-11(15)16)5-10-12(17)14-13(20)21-10/h2-5H,6H2,1H3,(H,15,16)(H,14,17,20)
InChi Key
DVBJNSKWHSGTDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $68

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    10 mg

    $127

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    50 mg

    $531

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    100 mg

    $928

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    Cayman Chemical
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    Product Description

    IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Item No. 27920).1 It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CFB1, suppressor of Hairless, Lag-1 (CSL) transcription factor. IMR-1A increases multiciliation in primary choroid plexus cancer cells when used at a concentration of 25 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Astudillo, L., Da Silva, T.G., Wang, Z., et al. The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis. Cancer Res. 76(12), 3593-3603 (2016).

    2. Li, Q., Han, Z., Singh, N., et al. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death Differ. 29(8), 1596-1610 (2022).