An ionizable cationic lipid
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BAMEA-O16B

Item No. 37439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-((3-methyl-9-oxo-10-oxa-13,14-dithia-3,6-diazahexacosyl)azanediyl)dipropionate
CAS Number
2490668-30-7
Synonyms
  • BAMPA-O16B
Molecular Formula
C56H111N3O6S6
Formula Weight
1114.9
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
O=C(CCNCCN(CCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O)C)OCCSSCCCCCCCCCCCC
InChi Code
InChI=1S/C56H111N3O6S6/c1-5-8-11-14-17-20-23-26-29-32-48-66-69-51-45-63-54(60)35-38-57-39-42-58(4)43-44-59(40-36-55(61)64-46-52-70-67-49-33-30-27-24-21-18-15-12-9-6-2)41-37-56(62)65-47-53-71-68-50-34-31-28-25-22-19-16-13-10-7-3/h57H,5-53H2,1-4H3
InChi Key
WBCDKXLTOZQTMM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

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    25 mg

    $277

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    50 mg

    $520

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    Cayman Chemical
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    Product Description

    BAMEA-O16B is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro and in vivo. LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) accumulate in the liver and decrease serum PCSK9 levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Chang, J., Jiang, Y., et al. Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles. Adv. Mater. 31(33), e1902575 (2019).