An α-synuclein knockdown peptide
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Tat-βsyn-degron (trifluoroacetate salt)

Item No. 37442

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-threonyl-L-lysyl-L-serylglycyl-L-valyl-L-tyrosyl-L-leucyl-L-valylglycyl-L-arginyl-L-arginyl-L-arginyl-glycine
Molecular Formula
C132H237N59O31 • XCF3COOH
Formula Weight
3146.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-YGRKKRRQRRRRTKSGVYLVGRRRG-OH
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(O)C=C2)N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C132H237N59O31.C2HF3O2/c1-68(2)60-91(119(219)190-99(69(3)4)120(220)170-64-96(198)173-79(29-16-52-160-125(142)143)106(206)177-83(30-17-53-161-126(144)145)109(209)174-77(27-14-50-158-123(138)139)103(203)171-66-98(200)201)186-118(218)92(62-73-39-43-75(195)44-40-73)187-121(221)100(70(5)6)189-97(199)65-169-104(204)93(67-192)188-115(215)82(26-10-13-49-135)185-122(222)101(71(7)193)191-117(217)89(36-23-59-167-132(156)157)183-113(213)86(33-20-56-164-129(150)151)180-111(211)85(32-19-55-163-128(148)149)179-112(212)87(34-21-57-165-130(152)153)182-116(216)90(45-46-94(137)196)184-114(214)88(35-22-58-166-131(154)155)181-110(210)84(31-18-54-162-127(146)147)178-108(208)81(25-9-12-48-134)176-107(207)80(24-8-11-47-133)175-105(205)78(28-15-51-159-124(140)141)172-95(197)63-168-102(202)76(136)61-72-37-41-74(194)42-38-72;3-2(4,5)1(6)7/h37-44,68-71,76-93,99-101,192-195H,8-36,45-67,133-136H2,1-7H3,(H2,137,196)(H,168,202)(H,169,204)(H,170,220)(H,171,203)(H,172,197)(H,173,198)(H,174,209)(H,175,205)(H,176,207)(H,177,206)(H,178,208)(H,179,212)(H,180,211)(H,181,210)(H,182,216)(H,183,213)(H,184,214)(H,185,222)(H,186,218)(H,187,221)(H,188,215)(H,189,199)(H,190,219)(H,191,217)(H,200,201)(H4,138,139,158)(H4,140,141,159)(H4,142,143,160)(H4,144,145,161)(H4,146,147,162)(H4,148,149,163)(H4,150,151,164)(H4,152,153,165)(H4,154,155,166)(H4,156,157,167);(H,6,7)/t71-,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,99+,100+,101+;/m1./s1
InChi Key
DHTOAOOUFFOQJU-INJORSAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $156

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    10 mg

    $294

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    25 mg

    $652

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    Product Description

    Tat-βsyn-degron is an α-synuclein knockdown peptide.1 It is composed of the HIV-1 Tat plasma membrane transduction domain, the α-synuclein binding domain βsyn which corresponds to amino acids 36-45 of β-synuclein, and the proteasomal targeting domain degron. Tat-βsyn-degron binds to recombinant α-synuclein in a peptide-protein binding assay and reduces α-synuclein levels in primary rat cortical neuron cultures, an effect that can be prevented by the proteasomal inhibitor MG132. In vivo, Tat-βsyn-degron (40 mg/kg) reduces brain α-synuclein levels in M38 transgenic mice that overexpress human A53T mutant α-synuclein. It also reduces phosphorylated α-synuclein levels in the substantia nigra and the pons, as well as neuroinflammation in a mouse model of spreading synucleinopathy induced by α-synuclein preformed fibrils. Tat-βsyn-degron (6 µmol/kg, i.p.) protects against dopaminergic neuron loss and rescues motor deficits in a mouse model of MPTP-induced Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jin, J.W., Fan, X., Del Cid-Pellitero, E., et al. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models. Commun. Biol. 4(1), 232 (2021).